![]() Highest efficiency two-photon degradable copolymer for remote controlled release. Olejniczak, J., Sankaranarayanan, J., Viger, M. Water-soluble, donor-acceptor biphenyl derivatives in the 2-(o-nitrophenyl)propyl series: highly efficient two-photon uncaging of the neurotransmitter γ-aminobutyric acid at λ + 800 nm. This study describes the wavelength-selective release of multiple therapeutics from a single biomaterial.ĭonato, L. Photoselective delivery of model therapeutics from hydrogels. Model studies for new o-nitrobenzyl photolabile linkers: substituent effects on the rates of photochemical cleavage. o-Nitrobenzyl photolabile protecting groups with red-shifted absorption: syntheses and uncaging cross-sections for one- and two-photon excitation. This study reports the first in vivo therapeutic release from photodegradable polymeric nanoparticles in the eye.Īujard, I. Light-responsive nanoparticle depot to control release of a small molecule angiogenesis inhibitor in the posterior segment of the eye. UV and near-IR triggered release from polymeric nanoparticles. Release from polymeric prodrugs: linkages and their degradation. Light control of insulin release and blood glucose using an injectable photoactivated depot. 4-Hydroxytamoxifen probes for light-dependent spatiotemporal control of Cre-ER mediated reporter gene expression. Photocleavable hydrogels for light-triggered siRNA release. Synthesis of a photocaged tamoxifen for light-dependent activation of Cre-ER recombinase-driven gene modification. Light-controlled gene silencing in zebrafish embryos. Light-triggered release of bioactive molecules from DNA nanostructures. Photoresponsive polymersomes as smart, triggerable nanocarriers. Photoresponsive real time monitoring silicon quantum dots for regulated delivery of anticancer drugs. Light-triggered release of ciprofloxacin from an in situ forming click hydrogel for antibacterial wound dressings. Synthesis and characterization of photolabile derivatives of serotonin for chemical kinetic investigations of the serotonin 5-HT 3 receptor. A., Wieboldt, R., Ramesh, D., Carpenter, B. Photocontrolled release using one-photon absorption of visible or NIR light. Photopharmacology: beyond proof of principle. Ultraviolet light-mediated drug delivery: principles, applications, and challenges. Stimuli-responsive materials for controlled release of theranostic agents. Photo-responsive systems and biomaterials: photochromic polymers, light-triggered self-assembly, surface modification, fluorescence modulation and beyond. Photoremovable protecting groups in chemistry and biology: reaction mechanisms and efficacy. Rapid photolytic release of adenosine 5′-triphosphate from a protected analog: utilization by the sodium:potassium pump of human red blood cell ghosts. Light-triggered multifunctionality at surfaces mediated by photolabile protecting groups. ![]() Photoreconfigurable polymers for biomedical applications: chemistry and macromolecular engineering. Chemistry and biological applications of photo-labile organic molecules. Finally, we highlight emerging tools and provide an outlook for the field of photoresponsive biomaterials. We survey various photochemistries for their applicability in vitro and in vivo and for the biochemical and biophysical modification of materials. In this Review, we discuss how light can be exploited to modify different biomaterials in the context of photomediated drug delivery and phototunable cell culture platforms. Photoresponsive biomaterials benefit from spatiotemporal tunability, which allows for site-specific therapeutic delivery in vivo and 4D modulation of synthetic cell culture platforms to mimic the dynamic heterogeneity of the human body in vitro. Moreover, model systems with modifiable physiochemical properties are needed to probe the effects of therapeutic molecules and to investigate cell–matrix interactions. When disturbances are well understood, correct biological function can be restored through the precise introduction of therapeutics. The spatiotemporal control of these interactions is essential for tissue function, and disruptions to this dialogue often result in aberrant cell fate and disease. Biological signalling is regulated through a complex and tightly choreographed interplay between cells and their extracellular matrix.
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